Enterosgel promoted intensive release of radionuclides from the body tissues and their excretion in the adsorbed form with feces, which justifies the use of sorbent in contamination. Accelerated release of radionuclides was the result of a general detoxifying action of Enterosgel and process of their direct binding in the GIT lumen. Enterosgel provides effective detoxification, direct and indirect decorporation of radionuclides and improves the functional state of the liver. We have also proved that administration of Enterosgel at work in the radioactive contamination area can be seen as immunoprotective method with indirect mechanism of action. Enterosgel shows hepatoprotective effect in healthy people and to a lesser extent – in patients with chronic liver disease.

The basic ways of removing the majority of incorporated radionuclides are through the gastrointestinal tract, liver and kidneys, therefore, these organs receive the highest internal radiation. In the liver up to 15% of radionuclides are accumulated, while many radionuclides are actively resorbed in the intestinal lumen back into the blood after their withdrawal from tissue depots with the bile, gastric and pancreatic juice. Considering contradictions of the experimental data on the effects of ionizing radiation on the liver and a very small number of clinical observations, the question of studying the impact of radionuclides in the liver is challenging.

Clinical evidences

EFFECT ENTEROSORBENT ENTEROSGEL ON THE LIVER CONDITION OF PATIENTS WITH CHRONIC INTERNAL EXPOSURE INCORPORATED RADIONUCLIDES
Dedenko I.K., Siksay L.T., Bandurin A.Yu.
National A.A. Bohomolets Medical University, Ministry of Healthcare of Ukraine, Uzhgorod, Ukraine, 1990
Open

STUDY REPORT
February 10, 1994
ON ESTABLISHMENT OF LARGE-SCALE PRODUCTION AND HEALTHCARE IMPLEMENTATION OF NOVEL HIGHLY EFFECTIVE POLYORGANOSILOXANE-BASED ADSORBENT DRUGS WITH DETOXIFYING EFFECT
Bezlyuda N.P., Baranyuk A.P.
Main Military Clinical Hospital of the Ministry of Defence of Ukraine, Kiev, Ukraine
Novel
Open

WASHOUT OF RADIOACTIVE CESIUM AND STRONTIUM BY ENTEROSGEL IN LABORATORY ANIMALS
Lysenko N.P., Volkov M.Yu.
Ministry of Agriculture of the Russian Federation,
Federal State-funded Educational Institution of higher professional education “Moscow State Academy of Veterinary Medicine and Biotechnology named after K.I. Skryabin”, Moscow, Russia, Akademika Skryabina str., 23, 109472 Moscow, Russia, www.mgavm.ru
Nikolay Lysenko – +79036734176 (Doctor of biological sciences, Professor, Head of Department of Radiobiology and Biophysics named after A.D. Belov, FSI “MSAVMB named after K.I. Skryabin”)
Mikhail Volkov – +79161457101 (Doctor of biological sciences, Professor, Department of Biotechnology, FSI “MSAVMB named after K.I. Skryabin”)