А. B. Petukhov et al. investigated the effectiveness of Enterosgel in the treatment of gastrointestinal diseases associated with indigestion and impaired absorption [1]. This trial enrolled adult patients with malabsorption syndrome, post-gastric resection syndrome, disorders following small intestinal resection and right-sided hemicolectomy, as well as patients with irritable bowel syndrome.

In the experimental group, patients were given Enterosgel for 21 days along with conventional treatment. Controls received conventional therapy only. The experimental group patients reported a subjective improvement as early as in 3 days in 85.7% of cases. In 10 to 12 days, all patients administered Enterosgel had normalized stool frequency, a trend towards better formed feces, and no more pain or dyspepsia; there were also coprogram improvements and favourable changes in the large intestinal microflora composition. In the control group, improvements began after 18 to 20 days of treatment. Additionally, the experimental group patients had decreased total bilirubin, cholesterol, urea, and uric acid concentrations; as well as normalized antioxidant index as a result of elimination of free radical oxidation products. Endoscopic and morphological-functional examinations conducted in the patients given Enterosgel revealed increased mucous membrane thickness and longer intestinal villi along with more shallow intestinal crypts, less oedema, less pronounced microhemorrhages and lymphocytic infiltration of the epithelium, as well as increased amounts of plasmacytes in the lamina propria of the mucous membrane. No adverse drug reactions were observed in the patients treated with Enterosgel.

Clinical evidences

1. Petukhov AB, Lysikov YuA, Shakhovskaya AK, et al. [Outcomes of Enterosgel therapy in the treatment of gastrointestinal diseases associated with digestion and absorption abnormalities]. In: Maev IV, Shevchenko YuN, Petukhov AB, ed. [Clinical application of Enterosgel in patients with gastrointestinal disturbances: novel approaches to treatment: Guidelines for physicians]. M.: 2000:21–27 (in Russian).