The medications that can cause severe liver damage include even such widespread pharmaceuticals as paracetamol. Simultaneously, the advertisement and unrestricted sale of medication works towards its very wide application. Uncontrolled use of paracetamol is associated with a high risk of complications. According to data from medical centers in the USA and the UK, overdoses of paracetamol is one of the main causes of acute hepatic failure, which results in the death of patients in many cases.

When analyzing the results obtained, one can state that the use of the enterosorbent Enterosgel after intoxication with paracetamol most efficiently decreases the LPO processes in the one- and twelve-month old white rats. The plasma level of MDA in the six-month old white rats of all groups under study did not change significantly compared to the one- and twelve-month old animals. This is evidence of high adaptive resources of adult organisms under the condition of influence of exogenous xenobiotics.

Clinical evidences

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UDK 615.212.099-06:616.15:612.015.11-085.246.9]-092.9

AGE CHANGES OF ANTIOXIDANT-PROOXIDANT BLOOD STATUSES IN RATS DURING PARACETAMOL POISONING AND THEIR CORRECTION WITH ENTEROSGEL Koval M.I., Pokotylo O.S. Ya. Horbachevsky Ternopil State Medical University, Ternopil, Ukraine 2008 Open