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CLINICAL EFFICACY OF ENTEROSORPTION IN TREATMENT OF MICROBIAL-INFLAMMATORY AND IMMUNOCOMPLEX KIDNEY DISEASES IN CHILDREN

I.V. Bagdasarova, Institute of Nephrology AMS of Ukraine, O.I. Osadchaya, А.М. Boyarskaya, Institute of Hematology and Transfusiology AMS of Ukraine, B.S. Sheyman, N.А. Voloshina, L.I. Medved Institute of Ecohygiene and Toxicology, the Ministry of Health of Ukraine.

The use of enterosorption with Enterosgel medication in combination therapy of children with acute pyelonephritis reduces the toxic load on the neutrophilic granulocytes and contributes to the preservation of functional activity of the given cells at subcompensated level, reducing the risk of generalization of infection and the development of associated complications.

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2016, ENTEROSORBENT ENTEROSGEL IN CLINICAL PRACTICE

T. Miksa

ln order to assess the characteristics of the medical device ENTEROSGEL, establish the method of its use and the safety for users, this report was drawn up in the form of a critical evaluation of the relevant published clinical studies conducted with ENTEROSGEL and with other at least partially comparable medical devices already placed on the European market.

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2016, EFFICIENCY OF ENTEROSGEL IN CORRECTION OF SYSTEMIC ENDOTOXEMIA IN CHILDREN WITH ATOPIC DERMATITIS

T.G. Malanicheva, B.A. Shamov

Objective: to define level of systemic endotoxemia in children with AD and evaluate drug Enterosgel (polymethylsiloxane polyhydrate) in complex therapy of the pathology.

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2015, EFFICIENCY OF ENTEROSGEL IN KIDNEY DISEASES IN CHILDREN LIVING IN THE THE CEMENT INDUSTRY REGION

Kudin M.V., Tsaregorodtsev A.D., Fedorov Y.N., Dlin V.V.

Nowadays the problem of interaction between the environment chemical composition and the health of the population is a challenge not only in Russia but also in other parts of the world. The level of overall health and quality of the environment (taking into account natural and anthropogenic factors) are to different extent determined by biogeochemical features in different regions of Russia. With intensification of industrial and human activities, urban growth, creation of "megalopolises" and major industrial centers the load has increased so intensively that a special ecological environment was formed, with high concentrations of anthropogenic products – i.e. with a serious pollution of air, soil and water basins.

 

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2015, COLLECTION OF RESEARCH PAPERS. ENTEROSGEL RESEARCHES

The term “enterosorption” has been proposed to define a method of sorption therapy based on daily oral administration of “enterosorbents”. Enterosorbents were known in the past because the tradition of eating natural clays in case of poisoning, for improvement of well-being, jugulation of diarrhea, and, possibly, for treatment of deficiency in microelements, goes back to bygone times, and as a phenomenon known as geophagia it was observed particularly in primates [6, 7]. However, Enterosgel, comparing to other sorbents has unique hydrophobic and selective sorption properties, which made it effective and safe in wide range of medical applications. Enterosgel has proven it’s safety and efficacy during 35 years of clinical studies and use in major hospitals of the Soviet Union, it is recommended in the official guidance of Ministry of Health for treatment of various diseases. Since 2008 Enterosgel is certified as a medical device class IIa and available as an OTC treatment in Europe.

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2015, APPLICATION OF ENTEROSORBENTS IN THE TREATMENT OF INTESTINAL INFECTIONS IN CHILDREN WITH CONCOMITANT ATOPIC DERMATITIS

Usenko D. V., Y. A. Gorelov, A. V. Rudyk

Acute enteric infections (AEI) are among the widely prevalent infectious diseases worldwide. The highest incidence of intestinal infections occur in pediatric populations [1]. The main reason is biodiversity pathogens AEI: bacteria, viruses and protozoa from different taxonomic groups. Bacterial AEI can cause the genera Salmonella, Shigella, pathogenic strains of E. coli, spp. Clostridium, spp. Campylobacter spp., spp. Staphylococcus spp. Klebsiella, etc. Viral AEI pathogens are group A rotaviruses and noroviruses, astroviruses, F adenoviruses, sapoviruses. Discusses the role of group C rotaviruses, bocaviruses, Aichi virus, parechovirus, coronaviruses, etc. in the development of acute gastroenteritis.

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2014, SAFETY DATA SHEET

Bioline Products s.r.o.

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2014, EUROPEAN SOCIETY FOR PEDIATRIC GASTROENTEROLOGY, HEPATOLOGY, AND NUTRITION/EUROPEAN SOCIETY FOR PEDIATRIC INFECTIOUS DISEASES EVIDENCE-BASED GUIDELINES FOR THE MANAGEMENT OF ACUTE GASTROENTERITIS IN CHILDREN IN EUROPE

Alfredo Guarino, Shai Ashkenazi, Dominique Gendrel, Andrea Lo Vecchio, Raanan Shamir, Hania Szajewska

Gastroenteritis severity is linked to etiology, and rotavirus is themost severe infectious agent and is frequently associated with dehydration. Dehydration reflects severity and should be monitored by established score systems. Investigations are generally not needed. Oral rehydration with hypoosmolar solution is the major treatment and should start as soon as possible. Breast-feeding should not be interrupted. Regular feeding should continue with no dietary changes including milk.

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2014, COLLECTION OF RESEARCH PAPERS. GASTROENTEROLOGY: NEW APPROACHES

Extensive clinical experience on the use of an innovative intestinal adsorbent Enterosgel has been accumulated over the past 20 years. Enterosgel provides a wide range of the therapeutic effectiveness due to its ability to bind toxins, allergens and pathogens in the gastrointestinal tract and eliminate these from the body.

The results of clinical studies of using Enterosgel in gastroenterology are presented in the collection. Enterosgel has proven itself as an effective agent for the treatment of peptic ulcer disease, inflammatory bowel disease, and diseases of the liver.

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2013, ENTEROSORBENTS THERAPY IN CHILDREN WITH ASTHMA LIVING IN POOR SANITARY CONDITIONS

Zaytseva N. , Usitnova O.

According to recent epidemiological and toxicological data, children living in poor sanitary conditions develop abnormal physical characteristics, such as morphological abnormalities and chronic diseases of the Central Nervous System and the respiratory, cardiovascular, musculoskeletal, endocrine and digestive Systems. Among the substances of industrial origin, an important role is played by metals that accumulate in the tissues and organs. The toxic effects are due to the type of metal, its concentration, the concurrence of other pathological factors and the general health conditions (immune reactivity, hypersensitivity, etc.). The study was conducted on 236 children suffering from mild asthma (experimental Group) living in areas close to metallurgical plants. 

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2013, COLLECTION OF RESEARCH PAPERS. ALLERGOLOGY, IMMUNOLOGY, DERMATOLOGY: NEW APPROACHES

Extensive clinical experience on the use of the innovative intestinal adsorbent Enterosgel has been accumulated over the past 20 years. Enterosgel provides a wide range of the therapeutic effectiveness due to its ability to bind toxins, harmful substances, pathogens and allergens in the gastrointestinal tract and eliminate these from the body. This collection of research papers presents study results of the application of Enterosgel in allergology, immunology and dermatology. Enterosgel was shown to be an effective treatment for asthma, dermal-respiratory syndrome, food allergy, urticaria, atopic dermatitis, acne vulgaris.

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2012, THE MANAGEMENT OF ACUTE GASTROENTERITIS IN CHILDREN

M. Plescik-Lech, R. Shamir, A. Guarino, H. Szajewska

Convincing evidence has accumulated showing that ondansetron reduces the risk for vomiting; however, a clearance on safety in children is needed. New evidence has reconfirmed that in Europe, where zinc deficiency is rare, there is no benefit from the use of zinc. New data, although mainly from outside of Europe, have reconfirmed that either smectite or racecadotril is an effective adjunctive therapy to oral rehydration. There is a clear effect of using certain probiotics, such as Lactobacillus GG or S. boulardii.

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2011, MEDICAL TREATMENT IN DETAILS: USE ENTEROSORBENT FOR MODIFYING THE MICROBIOTA IN PATIENTS WITH DIVERTICULAR DISEASE

Fedorova O.V., Fedulova E.N., Tutina O.A., Shumilova O.

A high clinical efficiency of Enterosgel preparation has been determined and its positive effect on the intestinal mucosa condition, digestion and absorption processes, the composition of small and large intestine-related microflora. The immunomodulative effect has been identified as conditioned by the normalization of eubiosis and the decreased inflammation activity in the intestinal mucosa.

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2011, ENDOGENOUS INTOXICATION IN INFLAMMATORY BOWEL DISEASE IN CHILDREN: SUBSTANTIATION OF DETOXIFICATION THERAPY USING ENTEROSORPTION METHOD

Fedorova O.V., Fedulova E.N., Tutina O.A., Korkotashvili L.V.

IBD in children is accompanied by the development of endogenous intoxication, manifestation of which is conditioned by the severity of the process and dependent on the nature of intestinal lesion.

Enterosorption is an effective and safe method of sorption detoxification in the combination treatment of IBD in children, since it reduces the toxic load on the detoxification system of the body and the risk of developing infectious and autoimmune complications.

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2011, CYTOPROTECTIVE EFFECT OF ENTEROSORPTIVE THERAPY OF CHILDREN WITH INFLAMMATORY INTESTINAL DISEASES (IID)

Fedorova O.V., Fedulova E.N., Tutina O.A.

Consequently Enterosgel creates comfortable conditions for development of the normal microflora and improvement of the microbiological landscape of the intestine. Cytoprotective properties of the preparation are stipulated by restoration of the intestinal barrier accompanied by increase of sIgA secreted by cells of the mucous membrane of the intestine, restoration of the structure of the microcirculatory race and positive morphologic dynamics.
Apparent clinic efficiency with the distinct cytoprotective effect and comfortable pharmaceutical form enable to recommend Enterosgel for wide application with children with IID for the purpose of sorption efferent therapy.

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2010, THE DETOXIFYING POTENTIAL AND CLINICAL EFFECTIVENESS OF THE ENTEROSORBENT ENTEROSGEL IN THE COMBINATION THERAPY OF VARIOUS DISEASES IN CHILDREN AND ADULTS

Nagornaya N.V., Dubovaya А.V.

The article describes different types of intoxication, presents a method of intracorporeal detoxification, and includes a classification of gastrointestinal adsorbents (enterosorbents). It summarizes the experience that has been gained with the intestinal adsorbent Enterosgel in the combination therapy of children and adults suffering from allergic diseases, gastrointestinal disorders, burn disease, chronic pyelonephritis, and recurrent non-specific vaginitis.

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2010, PERSPECTIVES IN THE USE OF ADSORBENT ENTEROSGEL IN NEWBORNS WITH HEMOLYTIC DISEASE

Arajev N.L., Vasilčenko L.V., Breděljeva N.K., Merikova N.L.

Treatment method of intestinal adsorption with Enterosgel made in the early days in newborn infants with isoimmune hemolytic disease is pathogenetically substantiated, provides more favorable course of the pathological process, the positive dynamics laboratory markers leads to a lower number of exchange blood transfusions and phototherapy sessions, reduces the risk of infection in newborns and shortens the period of inpatient stay. The intake of Enterosgel is safe, its implementation is simple and affordable.

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2010, ENTEROSOBTION IN PAEDIATRIC PRACTICE: SELECTION OF OPTIMAL SORBENT

N.V. Nagornaya, M.P. Limarenko, M. Gorky National Medical University of Donetsk

The main properties of enterosorbent Enterosgel®(paste) were analyzed. It was found that sorptiondetoxication action of this medication improves the state of gastrointestinal tract and mucous membranes, and evokes a number of positive "distant" effects, such as inhibition of lipid peroxidation, decrease in the content of circulating immune complexes and pro-inflammatory cytokines, subcompensation of immunodeficiency, activation of liver and kidney function, etc. Besides, this medication is quite safe. The inclusion of detoxicant Enterosgel® in the combined therapy allows to significantly improve the results of treatment of various diseases in children.

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2010, ABOUT EXPERIMENTAL PRECLINICAL SAFETY STUDYING OF THE MEDICINAL FORM OF A PREPARATION «ENTEROSGEL®,PASTE FOR INTAKE (SWEET)» GIVEN «TNK SILMA LTD.» (MOSCOW)

THE STUDY DRUG SAFETY OF "ENTEROSGEL®, PASTA FOR INTAKE (SWEET)" ALLOWS TO RECOMMEND ITS SUBMISSION TO THE TO THE MINISTRY OF HEALTH OF THE RUSSIAN FEDERATION AS LOW-TOXICITY DRUG AS THE PROCEDURE FOR EXPANDING INDICATIONS AND CHANGES IN INSTRUCTION FOR USE.

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2009, USE OF THE ENTEROSGEL IN COMBINED THERAPY OF PYELONEPHRITIS IN CHILDREN

Bagdasarova I.V., Fomina S.P., Lavrenchuk O.V., Osadchaya O.I., Sheiman B.S., Bagdasarov R.V.

Prevalence of urinary system diseases in Ukraine is 37 per 1000 children and tends towards constant growth. Among the urinary tract infections pyelonephritis (PN) is the most serious problem, which occupies a leading place among nephrology pathologies of childhood [3, 4]. In the recent years, an increase of recurrent and latent disease types is often accompanied by development of intoxication syndrome, probably caused by agents of toxin production, as well as by response of the body, with the development of endotoxemia, metabolic and immune distress.

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2009, CLINICAL AND EPIDEMIOLOGICAL FEATURES, THERAPY ISSUES OF NOROVIRUS INFECTION IN CHILDREN

Doroshina E.A.

Acute intestinal infections (AII) is one of the important health issues in both developing and developed countries, being the next widespread among mass infectious diseases after respiratory infections. Despite the progress made in improving diagnostics and treatment tactics, acute intestinal infections are widespread - they are transferred annually by at least 500,000 children (Onishchenko G.G., 2006; Uchaikin V.F., 2007; Feklisova L.V., 2007). In recent years there has been a clear trend in etiological significance of pathogens causing acute intestinal infections in
children (Gorelov A.V., Milutin L.N., 2006). There is no doubt that among them a leading role in the world belongs to viruses causing 50-80% of AII in children (Glass R., 2005; Parashar V., 2003 Podkolzin A.T., 2005). AII represent the greatest danger for the children in the first years of life due to high rates of morbidity and mortality worldwide (Sharapova O.V., Korsun A.A., 2003; Glass R.I. et al, 2000; Wilhelmi I. 2003.).

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2007, APPLICATION OF ENTEROSGEL IN COMPLEX TREATMENT OF NEONATES WITH PERINATAL PATHOLOGY

Mizgina T.I., Gurobska L.І., Goryachevska Т.М., Krykotenko L.V.

The article discusses the best practice of Enterosgel application in infants with perinatal pathology. High efficiency of Enterosgel has been shown in complex therapy of patients with neonatal hyperbilirubinemia, intestinal dysbiosis and other pathologies. Enterosgel has practically no side effects and is easy to use, being tolerated by the infants; it can also be used for fast and effective non-invasive detoxification.

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2005, EXPERIENCE OF ENTEROSGEL APPLICATION IN THE CLINICAL UNIT OF CHILDHOOD ALLERGIC DISEASES

Lasitsya A.I. , Okhotnikova A.M., Revutskaya G.E., Gritsishina S.M., Tsigankova I.S.

To evaluate the efficacy of the combined treatment using Enterosgel in the children with the pathology in the form of dermal respiratory syndrome (DRS).

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2004, ROTAVIRUS INFECTION IN NEWBORNS CHILDREN: CLINICAL PERFORMANCE, TREATMENT AND PROPHYLAXY

TUNDA I. P.

Health Care Practice has proposed effective preventive measures based on the results of clinical and virological studies and determining RVI leading risk factors in infants.

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1999, ENTEROSGEL IN PEDIATRICS

Soboleva M.K., Zorkina T.V., Plotnikova O.V., Simantovskaya T.P., Golisheva M.N.

The problem of elimination of toxic substances from the body is one of the most pressing in pediatrics. Hemosorption, hemodialysis and plasmapheresis has been successfully used in pediatric practice for a long time; however, the risk of their use may exceed expediency in some cases (for example, in case of moderate toxicity). Pediatricians have been always interested in non-invasive detoxification methods, in this context we have piloted Enterosgel, a new enterosorbent, in addition to infusion therapy, plasmapheresis, and in some cases as the unique detoxification therapy.

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1998, EVALUATION OF THE EFFICACY OF ADMINISTRATION OF THE PERORAL SORBENT ENTEROSGEL IN CHILDREN WITH ACUTE ENTERIC INFECTIONS

Bandina O.N., Aleksandrov V.V., Aleksandrov V.S., Gerashchenko V.I.

The performed analysis showed that administration of Enterosgel in treatment of the patients with enteroidea allowed reducing the duration of hospital stay by 2-3 days, which is due to a faster normalization of stool and disappearance of the guiding symptoms. No adverse and hypersensitivity reactions were detected upon its administration.

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1998, EFFICACY OF THE CLINICAL APPLICATION OF ENTEROSGEL IN THE CLINICAL UNIT OF CHILDHOOS DISEASES OF I.M. SECHENOV MOSCOW MEDICAL ACADEMY

Baranov A.A., Geppe N.A., Karpushkina A.V.

The medication Enterosgel offered by the enterprise "SILMA" approved itself as the efficient agent for treatment of various allergic pathology. Taking of Enterosgel by patients having the atopic genesis of bronchial asthma and dermatitis helps to arrest the broncho-obstructive syndrome and skin syndrome due to adsorption of allergens. Enterosgel allowed patients to withdraw from antihistamine drugs, reduce the administration time of bronchial spasmolytics. It showed a high clinical activity in the therapy of both acute and chronic digestive diseases.
Thus, Enterosgel is the efficient supplement to conventional treatment of allergic and gastrointestinal diseases in children.

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1997, USE OF ENTEROSGEL IN THE TREATMENT OF ROTAVIRUS INFECTION IN THE NEWBORNS

Dzjublik I.V., Kham E.E., Barbova A.I.

The results of clinical and laboratory research confirmed high efficiency of use of Enterosgel in the treatment of newborn infants with rotavirus infection. Regarding the data collected, it is possible to draw a conclusion about the possibility and the need to use Enterosgel for treatment of diarrhea caused by rotavirus in newborns and prevention of infectious complications.

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1997, ADSORPTION ACTIVITY OF ENTEROSGEL TOWARD ROTAVIRUS

Jilin V.N., Dzyublik I.V., Barbova A.I.

Every year the range of problems associated with use of sorption technologies in various fields of medicine is expanding. Growing use of sorption processes, in turn, leads to improvement of the properties of older types of sorbents and creation of new sorbents with improved properties and enhanced sorption selectivity toward certain substances. Comparative medico-biological studies of various polymeric materials has shown prospectivity of medical use of organopolysiloxane adsorbents, particularly of polymethylsiloxane (PMS) and its hydrogel, Enterosgel, which consists of a spatially cross-linked porous matrix with a rigid globular structure formed by siloxane chain containing methyl and partially uncondensed hydroxyl groups in silicon atoms. The presence of hydrocarbon radicals provides high affinity of Enterosgel to organic substances (organophilic properties), that is to the toxic metabolites of various nature. In contrast to the known carbon sorbents and highly dispersity silicas, Enterosgel is characterized by apparent selectivity.

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