I.V. Bagdasarova, Institute of Nephrology AMS of Ukraine, O.I. Osadchaya, А.М. Boyarskaya, Institute of Hematology and Transfusiology AMS of Ukraine, B.S. Sheyman, N.А. Voloshina, L.I. Medved Institute of Ecohygiene and Toxicology, the Ministry of Health of Ukraine.
The use of enterosorption with Enterosgel medication in combination therapy of children with acute pyelonephritis reduces the toxic load on the neutrophilic granulocytes and contributes to the preservation of functional activity of the given cells at subcompensated level, reducing the risk of generalization of infection and the development of associated complications.
M.S. Barylko, P.V. Seliverstov, V.G. Radchenko
Enterosgel has positive effect on the clinical picture in patients with CRF at the predialysis stage due to its sorption action that helps reduce the endogenous intoxication and improve renal function; upon its use quality of life improves together with psycho-emotional states; Enterosgel has good tolerability, it is safe, improves functional state of the kidneys and can be recommended in the complex therapy of patients with CRF at predialysis stage, in an amount of a single dose 3 times a day 60 minutes before a meal for 4 weeks.
ln order to assess the characteristics of the medical device ENTEROSGEL, establish the method of its use and the safety for users, this report was drawn up in the form of a critical evaluation of the relevant published clinical studies conducted with ENTEROSGEL and with other at least partially comparable medical devices already placed on the European market.
Kudin M.V., Tsaregorodtsev A.D., Fedorov Y.N., Dlin V.V.
Nowadays the problem of interaction between the environment chemical composition and the health of the population is a challenge not only in Russia but also in other parts of the world. The level of overall health and quality of the environment (taking into account natural and anthropogenic factors) are to different extent determined by biogeochemical features in different regions of Russia. With intensification of industrial and human activities, urban growth, creation of "megalopolises" and major industrial centers the load has increased so intensively that a special ecological environment was formed, with high concentrations of anthropogenic products – i.e. with a serious pollution of air, soil and water basins.
The term “enterosorption” has been proposed to define a method of sorption therapy based on daily oral administration of “enterosorbents”. Enterosorbents were known in the past because the tradition of eating natural clays in case of poisoning, for improvement of well-being, jugulation of diarrhea, and, possibly, for treatment of deficiency in microelements, goes back to bygone times, and as a phenomenon known as geophagia it was observed particularly in primates [6, 7]. However, Enterosgel, comparing to other sorbents has unique hydrophobic and selective sorption properties, which made it effective and safe in wide range of medical applications. Enterosgel has proven it’s safety and efficacy during 35 years of clinical studies and use in major hospitals of the Soviet Union, it is recommended in the official guidance of Ministry of Health for treatment of various diseases. Since 2008 Enterosgel is certified as a medical device class IIa and available as an OTC treatment in Europe.
Radchenko V.G., Seliverstov P.V.
In the following research feasibility of sorbent Enterosgel® has been studied in predialysis patients with CRF. The work presented has scientifically proven that use of Enterosgel® is effective and safe.
Extensive clinical experience on the use of an innovative intestinal adsorbent Enterosgel has been accumulated over the past 20 years. Enterosgel provides a wide range of the therapeutic effectiveness due to its ability to bind toxins, allergens and pathogens in the gastrointestinal tract and eliminate these from the body.
The results of clinical studies of using Enterosgel in gastroenterology are presented in the collection. Enterosgel has proven itself as an effective agent for the treatment of peptic ulcer disease, inflammatory bowel disease, and diseases of the liver.
Extensive clinical experience on the use of the innovative intestinal adsorbent Enterosgel has been accumulated over the past 20 years. Enterosgel provides a wide range of the therapeutic effectiveness due to its ability to bind toxins, harmful substances, pathogens and allergens in the gastrointestinal tract and eliminate these from the body. This collection of research papers presents study results of the application of Enterosgel in allergology, immunology and dermatology. Enterosgel was shown to be an effective treatment for asthma, dermal-respiratory syndrome, food allergy, urticaria, atopic dermatitis, acne vulgaris.
THE STUDY DRUG SAFETY OF "ENTEROSGEL®, PASTA FOR INTAKE (SWEET)" ALLOWS TO RECOMMEND ITS SUBMISSION TO THE TO THE MINISTRY OF HEALTH OF THE RUSSIAN FEDERATION AS LOW-TOXICITY DRUG AS THE PROCEDURE FOR EXPANDING INDICATIONS AND CHANGES IN INSTRUCTION FOR USE.
Yakubcevich R.E., Hlyupina N.P., Savostyanik S.А., Kuznetsov О.Е.
In the recent decades, a steady increase in the number of patients with end-stage chronical kidney disease (CKD) has been observed all over the world. This makes the problem of CKD treatment one of the central in modern nephrology. Considerable progress of renal replacement therapy (RRT), scientific and technical achievements in the field of hemodialysis, widespread introduction of clinic peritoneal dialysis and kidney transplantation have created real conditions for the successful solution of this problem. Bad life prognosis and the inevitable disablement have gone, as well as necessity of absolute avoidance from active social and professional activity [7,11]. At the same time it has become clear that it is important not only to extend life, but also to ensure its high quality.
Paliy I.G., Shifris I.M., Shevchenko Yu.N., Kryzhanovskaya O.I.
This article is dedicated to the problem of optimization of treatment of the patients with chronic renal failure caused by different diseases of kidneys.
Bezlyuda N.P., Baranyuk A.P.
Novel intestinal and topical adsorbent drugs with detoxifying effect (studies were conducted in 1980-1990 by order of Main Military Clinical Hospital of the Ministry of Defense of Ukraine) were widely evaluated in military medical facilities. The Military Hospital of Kyiv (nowadays the Main Military Clinical Hospital of the Ministry of Defense of Ukraine) participated in the medical and biological evaluation of novel drugs from the beginning of their development (V.N. Fadeev, F.G. Novikov, N.P. Bezlyuda).