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USE OF ENTEROSORBENT ENTEROSGEL IN COMPLEX THERAPY OF ACUTE VIRAL HEPATITIS B WITH CONCOMITANT INTESTINAL DYSBIOSIS

Moroz L.V., Paliy M.G., Tkachenko T.V.

In this study, which enrolled 144 patients with acute viral hepatitis B, we investigated the peculiarities of acute viral hepatitides accompanied with dysbiotic disturbances and the possible ways to correct the latter using an enterosorbent Enterosgel, as well as the effects of this medicinal product on immunological markers. It has been established that adding enterosorbent Enterosgel to the comprehensive treatment of such patients contributed to toxidrome suppression, prompt regression of major clinical signs of the disorder, gastrointestinal microbiocenosis normalization and improvement of immunological markers. Enterosgel can be safely used in patients due to its good tolerability profile and absence of adverse effects.

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2016, ENTEROSORBENT ENTEROSGEL IN CLINICAL PRACTICE

T. Miksa

ln order to assess the characteristics of the medical device ENTEROSGEL, establish the method of its use and the safety for users, this report was drawn up in the form of a critical evaluation of the relevant published clinical studies conducted with ENTEROSGEL and with other at least partially comparable medical devices already placed on the European market.

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2016, ENTEROSGEL COLUMBIA LECTURE, (Part 2)

A.V.Khovanov

Innovative Gastro-absorption method. A novel cleansing system in prevention and treatment.

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2016, ENTEROSGEL COLUMBIA LECTURE, (Part 1)

A.V.Khovanov

Innovative Gastro-absorption method. A novel cleansing system in prevention and treatment.

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2015, ENTEROSORPTION IN EMERGENCE LUNG TUBERCULOSIS

Jugostran V.Ya., Sharikov Yu.N., Esaulova Т.А.

In a controlled open single center trials the results of chemotherapy newly diagnosed patients with pulmonary tuberculosis in combination with enterosorption one of three drugs: Enterosgel (polymethylsiloxane polyhydrate), aerosil or carbon sorbent. The effect on the performance of enterosorption intoxication and liver function during chemotherapy. As a result, due to hepatoprotective and detoxification effect enterosorption, managed to avoid the interruption of chemotherapy.

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2015, COLLECTION OF RESEARCH PAPERS. ENTEROSGEL RESEARCHES

The term “enterosorption” has been proposed to define a method of sorption therapy based on daily oral administration of “enterosorbents”. Enterosorbents were known in the past because the tradition of eating natural clays in case of poisoning, for improvement of well-being, jugulation of diarrhea, and, possibly, for treatment of deficiency in microelements, goes back to bygone times, and as a phenomenon known as geophagia it was observed particularly in primates [6, 7]. However, Enterosgel, comparing to other sorbents has unique hydrophobic and selective sorption properties, which made it effective and safe in wide range of medical applications. Enterosgel has proven it’s safety and efficacy during 35 years of clinical studies and use in major hospitals of the Soviet Union, it is recommended in the official guidance of Ministry of Health for treatment of various diseases. Since 2008 Enterosgel is certified as a medical device class IIa and available as an OTC treatment in Europe.

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2015, APPLICATION OF ENTEROSORBENTS IN THE TREATMENT OF INTESTINAL INFECTIONS IN CHILDREN WITH CONCOMITANT ATOPIC DERMATITIS

Usenko D. V., Y. A. Gorelov, A. V. Rudyk

Acute enteric infections (AEI) are among the widely prevalent infectious diseases worldwide. The highest incidence of intestinal infections occur in pediatric populations [1]. The main reason is biodiversity pathogens AEI: bacteria, viruses and protozoa from different taxonomic groups. Bacterial AEI can cause the genera Salmonella, Shigella, pathogenic strains of E. coli, spp. Clostridium, spp. Campylobacter spp., spp. Staphylococcus spp. Klebsiella, etc. Viral AEI pathogens are group A rotaviruses and noroviruses, astroviruses, F adenoviruses, sapoviruses. Discusses the role of group C rotaviruses, bocaviruses, Aichi virus, parechovirus, coronaviruses, etc. in the development of acute gastroenteritis.

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2015, APPLICATION OF ENTEROSGEL ENTEROSORBENT FOR TREATMENT OF INTOXICATION AND DIARRHEA SYNDROMES IN PATIENTS WITH AIDS DURING ANTIRETROVIRAL THERAPY

Yurchenko A.V., Nikolaev V.G., Mamyedova E.S., Antonenko Z.V., Fedorenko S.V., Riabokon S.V., Harytonyuk A.V., Babeshko Y.S.

1. Application of Enterosgel enterosorbent in the patients with AIDS in the development of adverse reactions to antiretroviral therapy promotes more rapid reduction of diarrhea and intoxication syndrome (disappereance of subjective complaints, reduction of mean values of intoxication indexes, rod nuclear cells and eosinophils, positive dynamics of reduce of transaminase average level).
2. No adverse reactions caused by Enterosgel has been identified during its application as a part of complex therapy of pathological conditions in HIV-infected patients.

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2014, SINGLE-CENTER, PROSPECTIVE, OPEN, CONTROLLED STUDY OF THE EFFICACY AND SAFETY OF THE ENTEROSGEL DESIGNATED TO TREAT HELICOBACTER PYLORI-ASSOCIATED CHRONIC GASTRODUODENITIS

Tkachenko E.I., Avalueva E.B., Skazyvaeva E.V., Ivanov S.V., Lapinskii I.V.

Enterosgel has a positive effect on the clinical performance of the disease and is effective in reducing the symptoms of intestinal dyspepsia and diarrhea in patients with Helicobacter pylori-associated gastroduodenitis.

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2014, SAFETY DATA SHEET

Bioline Products s.r.o.

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2014, EUROPEAN SOCIETY FOR PEDIATRIC GASTROENTEROLOGY, HEPATOLOGY, AND NUTRITION/EUROPEAN SOCIETY FOR PEDIATRIC INFECTIOUS DISEASES EVIDENCE-BASED GUIDELINES FOR THE MANAGEMENT OF ACUTE GASTROENTERITIS IN CHILDREN IN EUROPE

Alfredo Guarino, Shai Ashkenazi, Dominique Gendrel, Andrea Lo Vecchio, Raanan Shamir, Hania Szajewska

Gastroenteritis severity is linked to etiology, and rotavirus is themost severe infectious agent and is frequently associated with dehydration. Dehydration reflects severity and should be monitored by established score systems. Investigations are generally not needed. Oral rehydration with hypoosmolar solution is the major treatment and should start as soon as possible. Breast-feeding should not be interrupted. Regular feeding should continue with no dietary changes including milk.

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2014, COLLECTION OF RESEARCH PAPERS. GASTROENTEROLOGY: NEW APPROACHES

Extensive clinical experience on the use of an innovative intestinal adsorbent Enterosgel has been accumulated over the past 20 years. Enterosgel provides a wide range of the therapeutic effectiveness due to its ability to bind toxins, allergens and pathogens in the gastrointestinal tract and eliminate these from the body.

The results of clinical studies of using Enterosgel in gastroenterology are presented in the collection. Enterosgel has proven itself as an effective agent for the treatment of peptic ulcer disease, inflammatory bowel disease, and diseases of the liver.

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2013, COLLECTION OF RESEARCH PAPERS. ALLERGOLOGY, IMMUNOLOGY, DERMATOLOGY: NEW APPROACHES

Extensive clinical experience on the use of the innovative intestinal adsorbent Enterosgel has been accumulated over the past 20 years. Enterosgel provides a wide range of the therapeutic effectiveness due to its ability to bind toxins, harmful substances, pathogens and allergens in the gastrointestinal tract and eliminate these from the body. This collection of research papers presents study results of the application of Enterosgel in allergology, immunology and dermatology. Enterosgel was shown to be an effective treatment for asthma, dermal-respiratory syndrome, food allergy, urticaria, atopic dermatitis, acne vulgaris.

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2011, CYTOPROTECTIVE EFFECT OF ENTEROSORPTIVE THERAPY OF CHILDREN WITH INFLAMMATORY INTESTINAL DISEASES (IID)

Fedorova O.V., Fedulova E.N., Tutina O.A.

Consequently Enterosgel creates comfortable conditions for development of the normal microflora and improvement of the microbiological landscape of the intestine. Cytoprotective properties of the preparation are stipulated by restoration of the intestinal barrier accompanied by increase of sIgA secreted by cells of the mucous membrane of the intestine, restoration of the structure of the microcirculatory race and positive morphologic dynamics.
Apparent clinic efficiency with the distinct cytoprotective effect and comfortable pharmaceutical form enable to recommend Enterosgel for wide application with children with IID for the purpose of sorption efferent therapy.

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2010, ABOUT EXPERIMENTAL PRECLINICAL SAFETY STUDYING OF THE MEDICINAL FORM OF A PREPARATION «ENTEROSGEL®,PASTE FOR INTAKE (SWEET)» GIVEN «TNK SILMA LTD.» (MOSCOW)

THE STUDY DRUG SAFETY OF "ENTEROSGEL®, PASTA FOR INTAKE (SWEET)" ALLOWS TO RECOMMEND ITS SUBMISSION TO THE TO THE MINISTRY OF HEALTH OF THE RUSSIAN FEDERATION AS LOW-TOXICITY DRUG AS THE PROCEDURE FOR EXPANDING INDICATIONS AND CHANGES IN INSTRUCTION FOR USE.

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2009, CLINICAL AND EPIDEMIOLOGICAL FEATURES, THERAPY ISSUES OF NOROVIRUS INFECTION IN CHILDREN

Doroshina E.A.

Acute intestinal infections (AII) is one of the important health issues in both developing and developed countries, being the next widespread among mass infectious diseases after respiratory infections. Despite the progress made in improving diagnostics and treatment tactics, acute intestinal infections are widespread - they are transferred annually by at least 500,000 children (Onishchenko G.G., 2006; Uchaikin V.F., 2007; Feklisova L.V., 2007). In recent years there has been a clear trend in etiological significance of pathogens causing acute intestinal infections in
children (Gorelov A.V., Milutin L.N., 2006). There is no doubt that among them a leading role in the world belongs to viruses causing 50-80% of AII in children (Glass R., 2005; Parashar V., 2003 Podkolzin A.T., 2005). AII represent the greatest danger for the children in the first years of life due to high rates of morbidity and mortality worldwide (Sharapova O.V., Korsun A.A., 2003; Glass R.I. et al, 2000; Wilhelmi I. 2003.).

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2009, CLINICAL AND EPIDEMIOLOGICAL FEATURES AND THERAPY OF COLIBACILLOSIS IN CHILDREN IN THE MODERN STAGE

Bondareva A. V.

The purpose of this work is optimization of colibacillosis diagnosis and therapy in children based on a study of clinical and epidemiological features on the modern stage.

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2004, ROTAVIRUS INFECTION IN NEWBORNS CHILDREN: CLINICAL PERFORMANCE, TREATMENT AND PROPHYLAXY

TUNDA I. P.

Health Care Practice has proposed effective preventive measures based on the results of clinical and virological studies and determining RVI leading risk factors in infants.

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1998, EVALUATION OF THE EFFICACY OF ADMINISTRATION OF THE PERORAL SORBENT ENTEROSGEL IN CHILDREN WITH ACUTE ENTERIC INFECTIONS

Bandina O.N., Aleksandrov V.V., Aleksandrov V.S., Gerashchenko V.I.

The performed analysis showed that administration of Enterosgel in treatment of the patients with enteroidea allowed reducing the duration of hospital stay by 2-3 days, which is due to a faster normalization of stool and disappearance of the guiding symptoms. No adverse and hypersensitivity reactions were detected upon its administration.

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1998, APPLICATION OF THE MEDICATION ENTEROSGEL IN TREATMENT OF PATIENTS WITH ACUTE ENTERIC INFECTIONS

Semenov V.M., Dmitrachenko T.I., Provolotskii E.P., Lyakhovksaya N.V.

Thus, taking into account the results obtained, one can recommend the application of Enterosgel in treatment of the patients suffered from dysentery and salmonellosis. At the same time, one should appreciate that it is wise to administer the drug as early as possible after the onset of disease. Drug administration in the first day of disease allows one to avoid the etiotropic therapy upon mild and average-severe forms of dysentery. Drug administration in earlier terms allows one to reduce the duration of detoxication and rehydration therapy in the case of salmonellosis and to reduce the terms of bacterioexcretion in the case of hospital-acquired salmonellossis.

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1997, USE OF ENTEROSGEL IN THE TREATMENT OF ROTAVIRUS INFECTION IN THE NEWBORNS

Dzjublik I.V., Kham E.E., Barbova A.I.

The results of clinical and laboratory research confirmed high efficiency of use of Enterosgel in the treatment of newborn infants with rotavirus infection. Regarding the data collected, it is possible to draw a conclusion about the possibility and the need to use Enterosgel for treatment of diarrhea caused by rotavirus in newborns and prevention of infectious complications.

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1997, ADSORPTION ACTIVITY OF ENTEROSGEL TOWARD ROTAVIRUS

Jilin V.N., Dzyublik I.V., Barbova A.I.

Every year the range of problems associated with use of sorption technologies in various fields of medicine is expanding. Growing use of sorption processes, in turn, leads to improvement of the properties of older types of sorbents and creation of new sorbents with improved properties and enhanced sorption selectivity toward certain substances. Comparative medico-biological studies of various polymeric materials has shown prospectivity of medical use of organopolysiloxane adsorbents, particularly of polymethylsiloxane (PMS) and its hydrogel, Enterosgel, which consists of a spatially cross-linked porous matrix with a rigid globular structure formed by siloxane chain containing methyl and partially uncondensed hydroxyl groups in silicon atoms. The presence of hydrocarbon radicals provides high affinity of Enterosgel to organic substances (organophilic properties), that is to the toxic metabolites of various nature. In contrast to the known carbon sorbents and highly dispersity silicas, Enterosgel is characterized by apparent selectivity.

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