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2016, ENTEROSORBENT ENTEROSGEL IN CLINICAL PRACTICE

T. Miksa

ln order to assess the characteristics of the medical device ENTEROSGEL, establish the method of its use and the safety for users, this report was drawn up in the form of a critical evaluation of the relevant published clinical studies conducted with ENTEROSGEL and with other at least partially comparable medical devices already placed on the European market.

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2016, ENTEROSGEL COLUMBIA LECTURE, (Part 2)

A.V.Khovanov

Innovative Gastro-absorption method. A novel cleansing system in prevention and treatment.

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2016, ENTEROSGEL COLUMBIA LECTURE, (Part 1)

A.V.Khovanov

Innovative Gastro-absorption method. A novel cleansing system in prevention and treatment.

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2016, EFFICIENCY OF ENTEROSGEL IN CORRECTION OF SYSTEMIC ENDOTOXEMIA IN CHILDREN WITH ATOPIC DERMATITIS

T.G. Malanicheva, B.A. Shamov

Objective: to define level of systemic endotoxemia in children with AD and evaluate drug Enterosgel (polymethylsiloxane polyhydrate) in complex therapy of the pathology.

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2015, EFFICIENCY OF ENTEROSGEL IN KIDNEY DISEASES IN CHILDREN LIVING IN THE THE CEMENT INDUSTRY REGION

Kudin M.V., Tsaregorodtsev A.D., Fedorov Y.N., Dlin V.V.

Nowadays the problem of interaction between the environment chemical composition and the health of the population is a challenge not only in Russia but also in other parts of the world. The level of overall health and quality of the environment (taking into account natural and anthropogenic factors) are to different extent determined by biogeochemical features in different regions of Russia. With intensification of industrial and human activities, urban growth, creation of "megalopolises" and major industrial centers the load has increased so intensively that a special ecological environment was formed, with high concentrations of anthropogenic products – i.e. with a serious pollution of air, soil and water basins.

 

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2015, COLLECTION OF RESEARCH PAPERS. ENTEROSGEL RESEARCHES

The term “enterosorption” has been proposed to define a method of sorption therapy based on daily oral administration of “enterosorbents”. Enterosorbents were known in the past because the tradition of eating natural clays in case of poisoning, for improvement of well-being, jugulation of diarrhea, and, possibly, for treatment of deficiency in microelements, goes back to bygone times, and as a phenomenon known as geophagia it was observed particularly in primates [6, 7]. However, Enterosgel, comparing to other sorbents has unique hydrophobic and selective sorption properties, which made it effective and safe in wide range of medical applications. Enterosgel has proven it’s safety and efficacy during 35 years of clinical studies and use in major hospitals of the Soviet Union, it is recommended in the official guidance of Ministry of Health for treatment of various diseases. Since 2008 Enterosgel is certified as a medical device class IIa and available as an OTC treatment in Europe.

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2014, SAFETY DATA SHEET

Bioline Products s.r.o.

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2014, COLLECTION OF RESEARCH PAPERS. GASTROENTEROLOGY: NEW APPROACHES

Extensive clinical experience on the use of an innovative intestinal adsorbent Enterosgel has been accumulated over the past 20 years. Enterosgel provides a wide range of the therapeutic effectiveness due to its ability to bind toxins, allergens and pathogens in the gastrointestinal tract and eliminate these from the body.

The results of clinical studies of using Enterosgel in gastroenterology are presented in the collection. Enterosgel has proven itself as an effective agent for the treatment of peptic ulcer disease, inflammatory bowel disease, and diseases of the liver.

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2013, ENTEROSORBENTS THERAPY IN CHILDREN WITH ASTHMA LIVING IN POOR SANITARY CONDITIONS

Zaytseva N. , Usitnova O.

According to recent epidemiological and toxicological data, children living in poor sanitary conditions develop abnormal physical characteristics, such as morphological abnormalities and chronic diseases of the Central Nervous System and the respiratory, cardiovascular, musculoskeletal, endocrine and digestive Systems. Among the substances of industrial origin, an important role is played by metals that accumulate in the tissues and organs. The toxic effects are due to the type of metal, its concentration, the concurrence of other pathological factors and the general health conditions (immune reactivity, hypersensitivity, etc.). The study was conducted on 236 children suffering from mild asthma (experimental Group) living in areas close to metallurgical plants. 

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2013, COLLECTION OF RESEARCH PAPERS. ALLERGOLOGY, IMMUNOLOGY, DERMATOLOGY: NEW APPROACHES

Extensive clinical experience on the use of the innovative intestinal adsorbent Enterosgel has been accumulated over the past 20 years. Enterosgel provides a wide range of the therapeutic effectiveness due to its ability to bind toxins, harmful substances, pathogens and allergens in the gastrointestinal tract and eliminate these from the body. This collection of research papers presents study results of the application of Enterosgel in allergology, immunology and dermatology. Enterosgel was shown to be an effective treatment for asthma, dermal-respiratory syndrome, food allergy, urticaria, atopic dermatitis, acne vulgaris.

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2010, THE DETOXIFYING POTENTIAL AND CLINICAL EFFECTIVENESS OF THE ENTEROSORBENT ENTEROSGEL IN THE COMBINATION THERAPY OF VARIOUS DISEASES IN CHILDREN AND ADULTS

Nagornaya N.V., Dubovaya А.V.

The article describes different types of intoxication, presents a method of intracorporeal detoxification, and includes a classification of gastrointestinal adsorbents (enterosorbents). It summarizes the experience that has been gained with the intestinal adsorbent Enterosgel in the combination therapy of children and adults suffering from allergic diseases, gastrointestinal disorders, burn disease, chronic pyelonephritis, and recurrent non-specific vaginitis.

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2010, ENTEROSOBTION IN PAEDIATRIC PRACTICE: SELECTION OF OPTIMAL SORBENT

N.V. Nagornaya, M.P. Limarenko, M. Gorky National Medical University of Donetsk

The main properties of enterosorbent Enterosgel®(paste) were analyzed. It was found that sorptiondetoxication action of this medication improves the state of gastrointestinal tract and mucous membranes, and evokes a number of positive "distant" effects, such as inhibition of lipid peroxidation, decrease in the content of circulating immune complexes and pro-inflammatory cytokines, subcompensation of immunodeficiency, activation of liver and kidney function, etc. Besides, this medication is quite safe. The inclusion of detoxicant Enterosgel® in the combined therapy allows to significantly improve the results of treatment of various diseases in children.

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2010, ENTEROSGEL

Nikolaev V.G.

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2010, ABOUT EXPERIMENTAL PRECLINICAL SAFETY STUDYING OF THE MEDICINAL FORM OF A PREPARATION «ENTEROSGEL®,PASTE FOR INTAKE (SWEET)» GIVEN «TNK SILMA LTD.» (MOSCOW)

THE STUDY DRUG SAFETY OF "ENTEROSGEL®, PASTA FOR INTAKE (SWEET)" ALLOWS TO RECOMMEND ITS SUBMISSION TO THE TO THE MINISTRY OF HEALTH OF THE RUSSIAN FEDERATION AS LOW-TOXICITY DRUG AS THE PROCEDURE FOR EXPANDING INDICATIONS AND CHANGES IN INSTRUCTION FOR USE.

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2010, A CLINICAL AND IMMUNO-ALLERGOLOGICAL STUDY OF THE EFFICACY OF ENTEROSGEL IN FOOD ALLERGY

Melnykov O.F., Zabrodskaya L.V., Tymchenko M.D., Sydorenko  T.V., Naumova O.A.

This article demonstrates the clinical efficacy of Enterosgel in the treatment of food allergy. Enterosgel was shown to have beneficial effect on the allergy status and promote normalization of total serum IgE levels, early interferon, and pro-allergic cytokine (interleukin-5) concentrations in patients with food allergy manifesting by angioedema. The reported studies the benefits of gastrointestinal sorption (enterosorption) achieved with Enterosgel during the combination treatment in patients with food allergy manifesting by angioedema.

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2009, APPLICATION OF THE METHOD OF ENTEROSORPTION THERAPY BY SILICON ENTEROSORBENT ENTEROSGEL IN THE INTEGRATED TREATMENT OF ALLERGIC DISEASES

J. Bystroň

Verification of clinical effectiveness and monitoring of the laboratoty values profile in patients with dermatic (atopic dermatitis, hibes) and respiratory (allergic asthma and allergic rhinitis) allergic symptoms in the period of main disease recrudescence. The influence of ENTEROSGEL taken was tested as a complementary influence in terms of the conventional basic treatment. For the purpose of making comparisons the same group of patients was monitored within the period prior to application of ENTEROSGEL. 

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2008, A MODERN VIEW ON THE ISSUE OF ENTEROSORPTION: CHOOSING THE OPTIMAL DRUG

I. G. Paliy, I. G. Reznichenko

Enterosgel also exhibits selectivity towards microorganisms as it actively binds pathogenic and opportunistic microflora though does not inhibit the normal microflora, thus eliminating intestinal dysbiosis.

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2007, ENTEROSORPTION AS AN IMPORTANT METHOD OF TREATMENT OF ELIMINATING CHRONIC ENDOTOXIN AGGRESSION

Chernikhova E.A., Anikhovskaya I.A., Gataullin Yu.K., Zakirova D.Z., Ivanov V.B., Saveliev A.A., Yakovlev M.Yu.

The study of 25 patients with chronic inflammatory diseases (HID) in stage of remission has demonstrated efficiency of intestinal absorption method (enterosorption) to reduce significantly the total concentration of bacterial lipopolysaccharide (LPS) in the general circulation. Endotoxin aggression (EA) of intestinal etiology is a universal factor in the pathogenesis of many diseases and syndromes and may be the immediate cause of local inflammation, acute and chronic SIRS (systemic inflammatory response syndrome - systemic inflammatory response syndrome), allergic and autoimmune reactions.

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2005, EXPERIENCE OF ENTEROSGEL APPLICATION IN THE CLINICAL UNIT OF CHILDHOOD ALLERGIC DISEASES

Lasitsya A.I. , Okhotnikova A.M., Revutskaya G.E., Gritsishina S.M., Tsigankova I.S.

To evaluate the efficacy of the combined treatment using Enterosgel in the children with the pathology in the form of dermal respiratory syndrome (DRS).

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2001, APPLICATION OF THE ENTEROSORBENT ENTEROSGEL IN THE CLINIC OF OCCUPATIONAL DISEASES

Poteryaeva E.L., Bobrova S.V., Kazeka E.Z.

The procedural guidelines describes the main physicochemical properties of the enterosorbent "Enterosgel", its mechanism of action, indications for therapeutic or prophylactic application in patients suffering from chronic intoxication and working under exposure to industrial toxins.

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1999, RESULTS OF THE USE OF ENTEROSGEL PREPARATION FOR THE TREATMENT OF THE GIT ORGANS DISEASES IN RELATION WITH DISORDERED FOOD DIGESTION AND ABSORPTION

Petukhov A.B., Lysikov Yu.A., Shakhovskaya A.K., Maltsev G.Yu., Sokolnikov A.A., Vasiliev A.V.

The present problem’s urgency is known to steam from a practical lacking of any important advances in treatment modalities for as common diseases as pathological conditions of the small intestine with allergic manifestations as well as those due to the gastric and small intestine resections of different length (malabsorption syndrome), colonic pathology with dysbiosis manifestations (irritable bowel syndrome, constipation syndrome). At the same, it should be mentioned that the disponible modalities of selective enterosorption and nutritional correction of impaired homeostasis are not utilized sufficiently enough.

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1998, ENTEROSGEL IN THE COMPLEX THERAPY OF ALLERGIC DISEASES

Kudelya L.M. 

In the past decade, the methods of extracorporal detoxication, such as hemosorption, enterosorption, and applicative sorption, have found a wide utility in medicine. Enterosorption is a safe and efficient method, which is applied upon diseases of different etiology. Enterosorption can be used both as monotherapy and in combination with conventional therapy. The application of enterosorption in treatment of allergic diseases is especially feasible.
We studied the efficacy of the enterosorbent Enterosgel in the complex therapy of patients with
allergic diseases. All patients were divided in three groups.

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1996, POLYMETHYLSILOXANE SORBENTS IN THE COMPLEX TREATMENT OF ALLERGODERMATOSES

Poberezhnik O.Yu.

Peculiarities of allergodermatoses of different origin have been studied. Using the obtained results and taking into account clinical the characteristic, complex technique for allergodermatoses treatment with the use of enterosorption and application sorption with new preparations based on polymethyloxane sorbing gels and immobilized on their basis phytopreparations and antibiotics was developed. The new method proved to be highly effective for the treatment of the patients.

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1994, ON ESTABLISHMENT OF LARGE-SCALE PRODUCTION AND HEALTHCARE IMPLEMENTATION OF NOVEL HIGHLY EFFECTIVE POLYORGANOSILOXANE-BASED ADSORBENT DRUGS WITH DETOXIFYING EFFECT

Bezlyuda N.P., Baranyuk A.P.

Novel intestinal and topical adsorbent drugs with detoxifying effect (studies were conducted in 1980-1990 by order of Main Military Clinical Hospital of the Ministry of Defense of Ukraine) were widely evaluated in military medical facilities. The Military Hospital of Kyiv (nowadays the Main Military Clinical Hospital of the Ministry of Defense of Ukraine) participated in the medical and biological evaluation of novel drugs from the beginning of their development (V.N. Fadeev, F.G. Novikov, N.P. Bezlyuda). 

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